Hi,
I wondered if anyone has used a Nmn supplement before? I have read that in the U.K. a dose of 500mg daily may improve brain fog(memory) focus, depression and energy levels. I have read it also may also help with weight loss.
I have rrms and I am overweight and struggle to exercise due to fatigue. I have not long started Aubagio and wondered if this is ok to take with it.
Thanks
I would recommend you speak with your MS team first.
I agree you should clear it with your MS team first. I got a dusty answer to a similar question many years ago, but mainly because my neurologist at the time dismissed all supplements with lofty disdain and saw them as manufacturers of very expensive pee. But itās always worth checking for unhelpful interactions.
Yeah, I would defo check it first. Just wondered if anyone had/are using it before I speak to them.
Just sounded to be good.
I think one of the troubles with unregulated supplements is you donāt really know whatās in there, so itās particularly tricky for medics and pharmacists to give them a confident OK (even assuming that they believe whatever is in them is an active ingredient in the first place). So you might not get a very satisfactory answer when you ask the question
I am aware of that, I asked the question as it has been around for 15+ years and there was a previous thread regarding someone using it, so wondered if it was something anyone recently had tried. Just thought I would ask on this support group instead of wasting the ms teams time if it was something that was known not to be suitable for rrms. There has been clinical trials for it also recently I know so thought it was worth an ask. Iāll keep my questions for the ms team in future and not trouble anyone on here again.
Cheers for the pointless lecture.
Itās a shame you read the responses as a lecture it seems useful and unbiased to me.
My ms nurse nurse told me to stay away from google especially US websites so I guess based on that Iād speak to them first and make an informed decision based on your circumstancesā¦ pros and cons
Again, not a googled item. I had read research papers regarding it. Medical ones. And all I asked what if anyone on here had used it or knew anything else about it. Sick of repeating myself. And will be deleting my account as this is pointless. Thanks for your opinions but I am looking to speak to someone who has also researched this not just coming on to hound someone for considering something out of the box that god forbid might help them a little .
Why I said speak to your MS team is because youāre about to start a DMT you need to speak to your MS team as there could be possible drug interactions and that could have catastrophic results. Weāre just being cautious, as we are not medically trained just passing on experiences of life.
@animali I understand your first message which is fine itās the others who are repeating what you have said and that I have already addressed that I donāt understand why they are messaging just to repeat it. Plus what Iām asking about is a vitamin supplement not a prescribed drug.
I clearly said in my first reply that I would speak to my ms team before starting anything but just wanted to reach out to see if anyone on here had used it before. Nmn has been around since 2005 so someone surely has came across it.
I think - know that everyone on the forum tends to look out for each other in dealing with the complexities and ultimately little understood but devastating disease of MS.
I wonder, could you help us and provide a link to The research papers that you have read and in particular the clinical trial. I donāt think NMN is something that is at all well known to the MS community- certainly I havenāt heard of it - Iāve had RRMS for around 19 years and tend to keep an eye open for anything that helps. The only article I have found is one that seems to complain about mainstream medicine raising questions about it
Ok, subsequent to my earlier reply, I have found a couple of papers which say pretty much the same thing I.e that it can reduce drowsiness and , as the paper say ā fatigue in the afternoon and thus improve mobility. I am pretty - 100% - sure that they are not talking at all about fatigue which we MS sufferers have to face. I really canāt find anything on that. Iāve also found some reports of NMN making people feel sleepy.
Happy to be corrected but I donāt think NMN has anything to offer MS patients
The papers I read stated that in the trails when taken in the morning it can improve your fatigue and brain fog.
It is a derivative of vitamin b. Which I was told as someone with ms should take.
I doubt much out there would get rid of any ms symptoms but if it eases it a little and is ok to take then Iād be willing to try it to see. (Obviously I would check with the ms team that I could take it before taking it). Surely any improvement is a winner with the symptoms?
Just to add Iāve asked admin to remove the topic as itās more of an annoyance than a help.
Iāve also found papers on NAD ( Nicotinamide Adenosine Dinucleotide - I think - of which NMN is an intermediary - donāt really know what that means) and MS in terms of potential remyelination but they are way beyond my understanding
I believe with Nad+ there is a raised worry about its effects on the patients kidney and liver functions. Nmn which is a form of the nad+ but is a lower form of it (if that makes sense) is a bit more friendly to the patient than the nad+ and with the limit on the dose in the uk it is safer than Nad+ and safer than the higher USA dose of nmn which studies suggest it may āfeedā cancer cells in patients with cancer or high family history of cancer but the lower U.K. dose does not have this same level of risk. That I can see, studies come out all the time so I could be wrong.
I just thought it was food for thought.
https://www.mssociety.org.uk/about-ms/signs-and-symptoms/fatigue/managing-fatigue
Managing fatigue and possible treatments
If you have a look on reddit thereās some information regarding NMN. There was also information regarding just doing exercise as NMN canāt replace a sedentary lifestyle. But thatās not through choice in so many people with MS itās how the illness has affected them, or taken from them. Iāve read through some of the Reddit posts and they are conflicting, some saying in the long term itās not good for your body ( liver and kidneys)