My boss saw me stumbling one day and said "you should take more water with it". I work for the university medical school, and he is a nurse. He is well aware of my condition and the fact that my husband was an alcoholic who drank himself to death. Yet I still had to explain in small words why that particular statement offended me. Normally I'm very laid back and silly comments don't bother me, but that one hit a nerve.
Also, during a discussion with an OH Dr about my application for medical retirement, not only did she say that she thought my problems were down to anxiety and depression, she also said that she thought I might get better (I'm hoping that she meant that I might recover from this current relapse and not the entire thing), and that I might meet someone (in the context of me running myself ragged trying to do everything on my own). Some very stupid, naive things to say to me - luckily I'm bright enough to know when to hold my tongue, otherwise she would have been on the receiving end of some very sarcastic comments, which would not have helped.
Sometimes well meant, or silly throwaway comments hit harder than they should. That's just life.