Hopefully someone can help me. I have been on Rebif 44 for 2 years now and as I have not had a relapse in this time it appears to be working. However I can not get used to the injections. As the rebismart is quite large and heavy (I only have small hands!!) I find using it cumbersome sometimes. I do my best to rotate the sites but have huge red/purple marks which in some cases are painful even after a couple of weeks. I have tried hot & cold compresses to no avail. My MS nurse's only comment when I showed him the marks was that he had seen worse. I understand the need to continue but has anyone been using the new single dose pens? Are they better? Is there any advise on self injecting generally?