I was wondering if anyone had any experience of Mitoxantrone as a treatment. I started it about 3 years ago when i was really bad and wheelchair bound. Around this time I was told i probably had SPMS but maybe I had PPMS all along, nobody was too sure. It stabilised me and with a lot of physio I regained my walking and have been fairly stable until this year. Over the last 6 months or so things have started to gradually slide and walking is getting more and more difficult. i’ve tried steroids to bounce back a bit but they don’t seem to be doing the trick. I’m some way off my maximum dose of the Mitox but have people found that it stops being effective or is it just that my MS is getting worse.