Has anyone had a big operation with a general anaesthetic, and did the general make your neuro symptoms worse or make no difference? Last year I was diagnosed with demyelination of the central nervous system (MRI scan shows lesions on the brain, and I have some ongoing symptoms). Apparently I don’t meet all the criteria for MS, but MS is the nearest thing I’ve found to what I’ve got. Now I need a very big op (for something else) under a general anaesthetic - I’m petrified anyway, but especially worried about whether it could worsen the neuro symptoms. Getting an opinion from the MS consultant I saw is proving near impossible. Has anyone had a big op and can you tell me whether it affected your MS symptoms please?