I’ve been taking 100mg daily for about three weeks.
I realise that is well short of the doses that appeared promising in trials, but I’m cautious of these ultra-high doses “with no side effects”, because much the same theory was advanced for Vitamin D - until someone here did manage to overdose on it.
So my motto was - and still is - “moderation in all things”. I’m not sure anything in very high doses is safe and risk free - we know that you can die of drinking too much water. So I’m not yet satisfied that “the sky’s the limit” as far as dose is concerned, and am still on a very conservative dose.
In reality, I’m taking very slightly more than the 100mg, because I think one of my other supplements contains a trace amount of biotin, but still nothing like enough to take me to 300mg.
I may be on 105 or something.
Can’t say I’ve noticed anything so far.
Perhaps a few more times when I’ve gone right through the night without needing the loo, but they’re still the exception, rather than the rule, and much depends on how tired I was when I went to bed. IF I allow myself to get sufficiently tired (skip the afternoon nap), I seem to be able to sleep through the urge without having an accident - but still wake up busting, and can’t languish long in bed.
So I can’t say with any conviction there’s been a real improvement. I don’t know if this is because I’m not taking enough, or haven’t yet persevered long enough, or just because I’m going to be a non-responder.