Anyone used Frio wallets?

Just seen these online, designed for insulin really but suitable for keeping medications at room temp when travelling. They activate using cold water then work for a minimum of 45 hours. They can then be reactivated. Obviously they won’t keep things fridge cold, but when travelling abroad would keep Rebif under the 25 degrees for 14 days requirement. Do they work? And do they cause problems at airport security? X