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Anyone used Frio wallets?

Just seen these online, designed for insulin really but suitable for keeping medications at room temp when travelling. They activate using cold water then work for a minimum of 45 hours. They can then be reactivated. Obviously they won’t keep things fridge cold, but when travelling abroad would keep Rebif under the 25 degrees for 14 days requirement. Do they work? And do they cause problems at airport security? X

Would be really interested to hear about anyone using these too! I had a nightmare at the airport a few weeks ago with freezer packs. Still in Spain and hunting for freezer packs less than 100 ml so I can bring medicine home. Any tips gratefully received!