When I started on the Tizanidine I was told to start at 2mg at night only, building up to 2mg 3 x daily over a fortnight, then increase to 4mg, again at night and increasing the daily dose over another week or so, but I found that the 4mg made my legs too weak, even more so if taken with a meal.
When I checked out online why it felt stronger with a meal, apparently you should start taking it either with or without food, but DONT then alter how you take it in between, I guess it’s how the body gets used to absorbing it ?
I was usually taking it on an empty stomach, but now and then with food, because as it says on the instructions, “take with or without food”, but the absorption rate into the bloodstream goes through the roof if taken with food, at least thats what I found when reading up on it online ?
I definitely noticed an increase in weakness in my legs if I took it with a meal, and it comes on very quickly.
It’s odd really because 2mg does nothing, but 4mg can make my legs weak.
These types of drugs really are a bit of trial and error.