Hi everybody,
hope you are all not too bad today. Has anyone tried or is trying Clemastine? am surprised there is nothing on the forum I can see. Anyway…
http://multiple-sclerosis-research.blogspot.com/2016/04/aanremyelination-reality-will-biogen.html
Thanks,
Dave.
It looks quite promising for ON remyelination. Only up to phase 2 trials so far, but interestingly the trials haven’t had a big drop out rate which makes it more promising still since that seems to indicate that the side effects aren’t a big problem. Plus, since it’s not a new drug, it won’t be a case of waiting years for it to be licensed or agreed by NICE once the scientists have firmly decided that it works. Sadly, that means the drug companies are not going to make a fortune from it, so actually having it prescribed for MS remyelination is still likely to be some way away.
And it’s a drug for progressive MS as well as RR hooray. We need more of these.
Sue
No prescription required just over the counter I think, it’s an anti-histamine.
Dave99
ellie
Thanks for the link ellie. “… when used to treat allergy symptoms, side effects include drowsiness and fatigue” is a bit worrying. I’m one of those with MS caused fatigue.
l have read about this type of anti-histamine - working to help us with MS before. So l was interested in the Barts Blog re Clemastine. l have now ordered some - so it will be interesting to see what effect it has. l do not suffer with fatigue as l take B12 D3 and Biotin - plus of course LDN - ln fact l hardly sleep - so this Travegil [Clemastine fumerate] taken at night hopefully will help me sleep more then the usual 3 to 4 hrs.
l have ordered it from an online chemist. l had to fill in a questionaire - which l have answered honestly - saying it is for MS - and mentioning the Barts Blog. l could have lied and said it was for Rhinitis or dermatitis. So l shall soon see whether l get it.
l paid £7 for 60 + postage.
Order was cancelled and cost refunded. l should have lied and said l had hay-fever or dermatitis. Exactly the same tablets can be bought for dogs - l looked at several sites but all say Tavegil is ‘unavailable’. Need to get to a chemist.
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Order was cancelled and cost refunded. l should have lied and said l had hay-fever or dermatitis. Exactly the same tablets can be bought for dogs - l looked at several sites but all say Tavegil is ‘unavailable’. Need to get to a chemist.
[/quote] Won’t be holding my breath then.I declared i had MS and am on tablets for my heart for the rest of my life
Tried again a different online pharmacy- pharmacy24 - and this time it has gone through and they have said it has been dispatched - so watch this space.
Boots and Lloyds chemist should stock it - but l cannot get to them very easily.
My OH picked some up from our local chemist for me yesterday - so should be no problem getting them, which is not the impression I got from the comments on the Bart’s blog, but perhaps that’s just the US. They didn’t ask what they were for, so he didn’t offer any explanation.
Well done - l think if we want to try them we need to move quickly - as soon as the manufacturers find out why we want them they will up the price.
off topic a bit —
does the myelin of people who don’t have m.s. replace or repair itself?
Would it need to if its not under attack by the misguided immune system?
A neuro I saw some years ago said that in his opinion the myelin was not ‘attacked’ and had nothing to do with the immune system.
His theory was that we were either born with inadequate myelin or the ‘system’ whereby myelin repairs itself was faulty.
Presumably he came up with his theory before there were MRIs showing that myelin is attacked (inflammation shown on GD-enhanced MRIs) and that the brain shrinks as a result of the nerves dying after the myelin is attacked. If his theory was right, none of the very effective drugs we have now would work.
Well that was quick - they arrived this morning. Tavegil from pharmacy24.
I guess the mechanism that repairs myelin might work for any demylinating disease.