Not a link I was aware of however 100% Piriton (which is of the same type) puts me loony toons for some reason (PPMS). Does anyone else have any similar experiences?
Recognise that isn’t the subject of the study but separately a 33% having a 5x jump in progression with PPMS that’s epic.
'Of the nine patients on daily clemastine who completed at least one follow-up visit after six months of treatment, three (33.3%) experienced a progression of disability that was more than five times faster than before the treatment. The probability that this result occurred by chance was 0.015%, the researchers noted. ’
Hi,
Thanks for posting this finding on clemastine - I’d seen the press release but not the full journal article.
I think the Cambridge trial looking at clemastine plus metformin is still ongoing, so presumably they didn’t feel they had to suspend it on this basis - https://www.mssociety.org.uk/research/explore-our-research/search-our-research-projects/can-metformin-clemastine-repair-myelin-people-MS.
I’ve taken small doses of clemastine in the past with no impact on MS either way. But given the TRAP finding I wouldn’t take it now unless under close clinical supervision in a trial.