Not a link I was aware of however 100% Piriton (which is of the same type) puts me loony toons for some reason (PPMS). Does anyone else have any similar experiences?
Recognise that isn’t the subject of the study but separately a 33% having a 5x jump in progression with PPMS that’s epic.
'Of the nine patients on daily clemastine who completed at least one follow-up visit after six months of treatment, three (33.3%) experienced a progression of disability that was more than five times faster than before the treatment. The probability that this result occurred by chance was 0.015%, the researchers noted. ’
Hi,
Thanks for posting this finding on clemastine - I’d seen the press release but not the full journal article.
I think the Cambridge trial looking at clemastine plus metformin is still ongoing, so presumably they didn’t feel they had to suspend it on this basis - https://www.mssociety.org.uk/research/explore-our-research/search-our-research-projects/can-metformin-clemastine-repair-myelin-people-MS.
I’ve taken small doses of clemastine in the past with no impact on MS either way. But given the TRAP finding I wouldn’t take it now unless under close clinical supervision in a trial.
I’ve been reading up on Clemastine and its effects on Multiple Sclerosis (MS), and it’s definitely a topic worth discussing. While Clemastine is an antihistamine commonly used to treat allergies and hay fever, there’s been some concern about its potential effects on MS progression.
Some studies have suggested that antihistamines like Clemastine might have a negative impact on MS due to their sedative properties, which could lead to an increased risk of exacerbating MS symptoms. This could be due to the way Clemastine affects the central nervous system, potentially altering the function of neurons or immune responses in the brain and spinal cord.
However, there are also studies indicating that Clemastine could have some potential benefits in MS, particularly in terms of remyelination, which is the process of repairing the protective covering around nerves. This area of research is still evolving, and the potential benefits versus risks are not fully understood.
If you or someone you know has MS and is considering taking Clemastine or any antihistamine, I would strongly recommend discussing it with a neurologist. They can help weigh the risks and benefits, especially in relation to MS progression.
It’s always important to be cautious when it comes to medications and MS, as they can have complex and varied effects depending on the individual.