I think I’m driving myself crazy! A few weeks ago, I started feeling like a popping or twitching in my calves. Sometimes it happens in my thighs, but not as much. I dont have any numbness, but sometimes a slight tingling not in one particular area though. No muscle cramping. Once in a blue moon, it will happen in an arm, but not often. Occasionally I’ll get pain there also. My lower back pain seems to coincide with these feelings. MS is constantly on my mind, as I never had this before. I am 56 yrs old and also have Lupus and Fibromyalgia. Currently off all meds for the Lupus. Has anyone had this feeling as a first symptom without any other symptoms? My appt with a GP is in a month, as my anxiety about this is through the roof! I appreciate any help!