Kesimpta 1st & 2nd injections

Hi all,
I’m new to the site. Was diagnosed with Relapsing-remitting MS late 2024. Just had my 2nd Kesimpta jab yesterday following the 1st jab 8 days ago and thought I’d give feedback on my experience so for to the group, especially those due to start/considering choosing to go on Kesimpta treatment injections -

Before starting I watched countless you tube videos regarding side effects etc.
My 1st injection was to be with a MS nurse at hospital, I was quite anxious beforehand, I liken it to having to go to dentist to have a tooth taken out etc (you know not going to be nice, but necessary).

  • 1st injection in my upper thigh did it myself in front of MS nurse, no pain, very easy to do, took a matter of seconds, 1st click followed by 2nd click then that was it - No reaction for 1st three hours, then side effects suddenly hit, felt very unwell. Went to bed for 4 hours, it felt like i had been injected with a mini flu/covid (high temperature, body aching all over & headache etc), my son came into the bedroom to see me and i couldn’t lift my head off the pillow, let alone get out of bed. However 4 hours later by hour 7 the sympoms began to wear off. Got up the next morning, after a standard nights sleep, felt a bit heavy initially, but ok.

  • 2nd injection yesterday, yaken early evening as was keen not to have the whole day wasted -mild symptoms after 3 hours this time, light headache & body felt a bit heavy, only lasted a few hours.
    Got up this morning, no issues with sympoms.

Going forward 3rd injection next week, then week off, followed by monthly injections. Hopefully my body will be used to the injections and side effects not getting in the way of work & holidays etc.

Hopefully this feedback is helpful, especially to those newly diagnosed and considering what treatment to go on - so far so good with Kesimpta for me…

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Thank you for posting. I’ve chosen kesimpta as my DMT. The thought of it is scary, you’re right. Maybe just think of it as a powerful anti-inflammatory.

Did you take any pain killers or benadryl? Hopefully once you’re finished the loading doses you won’t get many side effects. It is supposed to be one of the better, more effective DMTs.

Hi, just saw your reply- Paracetamol for 2 days after 1st jab. No issues with side effects after jabs 2 and 3 (jab 3 was 4 days ago).
Thanks.