Not sure if my reply will be published, as I have done several replies to threads regarding Modafinil and they’ve always been queued for approval by mods but then never published!! so here goes anyway.
I have been on Modafinil since 2005. I now take the maximum dose of 400mg a day, and I know that I wouldn’t be able to function at all without it. As it is, I still have to take to my bed practically every afternoon for 2-3 hours, but I know, by the occasional time that I have not taken it, that I would have no life at all (if you can call it a life, lol) if it were to be withdrawn from me.
Prior to being prescribed Modafinil, I was on Amantadine, but it had no effect whatsoever.
I have recently had to change GP surgeries and my new GP was surprised that I was on Modafinil, and was unwilling to add it to my repeat prescriptions list, unless he had proof that I had been prescribed it from my neurologist!! Luckily I managed to get the proof and he reluctantly added it to my repeats, but I felt he was quite disapproving of it!
I hope you can find some answers as to why its now not approved for MS fatigue. My guess would be that its all down to cost, as I now it is a very expensive drug.