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DMD

Hi everyone, my first time on here. I have been diagnosed with RRMS for 20 years now and have been lucky enough to have not been affected very much, allowing me to treat myself with alternative therapies. I recently got sent for an MRI as I have had 3 relapses in the last year. They are offering me DMD, the neurologist said I can pick which one I want. I would appreciate some feedback from others that have been without treatment and then started on dmd’s. Thanks in advance

Hi Isis I have almost an identical situation to you and yesterday was offered a choice of DMDs. have you made a decision? I was looking at aubagio from the brief overview the spec gave me (fewer tests and no injections etc) but looking at the fact sheets on the website im now leaning towards Tecfidera as it has a better success rating than aubagio…

Hello Have you (both) seen the https://www.mstrust.org.uk/about-ms/ms-treatments/ms-decisions-aid ? It lists all the DMDs currently available. Your neurologist may have said ‘pick one’, but the chances are that you’ll be offered one of a selection. Some of the drugs are for ‘highly active’ MS and some only as a category two drug - such as Tysabri - generally available to someone who has been on a different DMD and ‘failed’ on it (ie, continued to relapse). I’d expect that you are offered all the old style injectables (beta interferons and Copaxone), plus Aubagio and Tecfidera (the two most common oral drugs). You may also be offered Gilenya and/or Ocrevus. I definitely think Tecfidera is a superior drug to Aubagio. As you’ve said Octopus, it has a better relapse reduction rate to Aubagio. Aubagio also has a long list of potential side effects, so to get a 30% relapse reduction rate but chance all the side effects, you’d be better off with a beta interferon (imo). A beta interferon such as Plegridy is worth considering, it’s injected only once a fortnight and has few side effects which many people manage quite well. So if you do what research you can, balance out the method of taking the drug, the potential side effect profile and the relapse reduction rate. If you opt for one drug and find it doesn’t suit you, it should be relatively easy to switch to another. Best of luck. Sue

Thanks Sue for your advice, I’ve been looking a lot at the ms trust. They did offer me a choice of dmd, they are all on the table was the quote from the neurologist! I’ve recently made a choice Octopus, gone for a avonex. I haven’t had any treatment so far, diagnosed 20 years ago, I like to do alternative treatments & have struggled to make a choice & accept that my ms wasn’t benign after all. I looked at the action of the drug 1st. I would of gone for tysabri but I was positive for the JC virus & didn’t want to take the risk. So we’ll see. Thanks again :slight_smile:

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Hello everyone. Read all the comments and you need to make the correct decision now as once you chose it is difficult to swap to something else for no real reason. I was offered a choice but my neurologist directed me to Tecfidera which I have been on for 4 years without a relapse and no problems it is like taking a smarty twice a day. I and my neurologist recently wanted me to change to Ocrevus but since I have had no relapses it was knocked back by a hospital committee. Ocrevus is ok for secondary progression which I now have. I also think it is the best option for me. Choose well and good luck, it is like tossing a coin or drawing lots. Bertie

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