That’s a very important question and I’m glad you asked it. Everybody tolerates (or not, as the case may be) these medications differently. It’s not like paracetamol.
I was given Amantadine for fatigue but I haven’t used any for months. I don’t know why. It might be my exercise regime (Tai Chi) or Vitamin B Strong Compound which, I’ve read, helps the body to extract energy from the storage cells more efficiently.
Baclofen immediately gave me nightmares, sleepless nights, muscle spasms and got me****angry. I was like Dr Jekyll one minute and then, without any reason, I’d turn into Mr Hyde. It scared my wife and it scared me. Last month I replaced it with Dantolene for the leg spasms. This was tricky as neither the MS Nurse nor my GP had any idea what the dose I should be taking. Very cautiously, I started on the minimum of 25 mg. After a week I could take 100 mg which is perfect
I used to take Pregabalin but it became less effective after a few years. It’s been replaced by Amiltriptyline which does the job. I now take one tablet of Amiltriptyline 25 mg and one of Dantolene 100 mg three times a day. I often need Co-codomol 30/500 as a back-up for the spasms in my upper arms,which the Dantolene doesn’t stop.
I’m afraid there’s no right answer. You have to discover what works for you by trial and error.