People swear blind that one should listen only to MS nurses for drug advice. It is true that they have certain (theoretical) insights, but i personally value far more, the practical experience of those popping the same pills. And thus, in the spirit of this:
If your ‘theoretical expert’ immediately recommends full dose in one or two weeks, they might not be your ‘best friend’. If they specifically recommend fatty or protein rich foods, they might be wasting your time. If they insist that you simply stay the course for three, side effect filled months before then quitting and finding an alternative drug, then they might care more about ticking boxes than your well being.
What i have learnt from nurturing an addiction to Tecfidera over the last 18 months:
you will need time for your body to grow accustomed to this new, dietary, foreign substance (aka positive poison). I strongly recommend the dosing schedule stated in post #5 of this thread. if at anytime, your side effects are not resolved with the actions listed below, simply reduce the daily dose to that of the previous week. (i think one pill daily for two weeks is ultra conservative, but hey… we are all different in our sensitivities).
Always take the pills mid-meal. (unless going to sleep immediately after, but this is expert level tecfidera taking; stomach cramps at 3am are no fun);
An aspirin before dose one = flush avoidance
paracetamol = stomach cramp cure
anti-histamine = flush / prickles / itch cure
And that is all. just take your tec at least four hours apart; ideally 12 hours apart… but don’t stress if this isn’t feasible. You might also notice that any side effects, IF they do arise, will do so around 3.5 to 4 hours after a dose. So if you get past the four hour threshold, you’ve made it!
good luck. soldier on. it is a doddle!