Tecfidera and sore throat, gastric problems

Has anyone had problems with acid reflux, worsening gastritis or chronic sore throat on Tecfidera? I’m taking omeprazol once a day, 20mg, but the DMT is still causing me these symptoms 4 months in, meaning i need to sleep with my head raised. When I pause the Tecfidera, my throat and stomach pain reduce. Obviously I’m not eating any trigger foods and I’m trying different antacids but it’s difficult to work as I keep losing my voice. Have you had this type of side effect? To be fair, I already had gastritis (but no reflux) before starting treatment but without H Pylori or many symptoms.

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I am sorry to read this. I hate it when I end up having to take a medicine to deal with the side effects of another medicine, and it gets me thinking about alternatives to the offending medicine. Is that worth considering and discussing with your medical advisors? Tecfidera isn’t the only show in town.

I agree. I´m waiting to be vaccinated which opens up more options. I have called the MS nursing team to pass on my tolerance problems to the specialist. Let´s see what he advises but the range of choice is both a good thing and also a bit overwhelming. All the DMTs seem to come with awful side effects…my neurologist is studying me for possible progression and after vaccination and MRI might suggest switching to Ocrevus if there is progression or I really can´t tolerate Tecfidera.

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It’s’ luck of the draw with side-effects, I think. I was on Avonex for 10 years and occasionally the morning after would have a feeling best described as a very mild and fleeting gin hangover. Tysabri has no side effects at all for me beyond a slight tiredness after treatment. Beyond that, it’s all upside. But I don’t think I would cheerfully have put up with the sort of troubles you are having - particularly when you have a history of gastritis already and know you have to treat your insides kindly.

Hi, I’ve been on Tecfidera for over 3.5 years. Cant say I’ve experienced any of the problems you describe. I would’ve suggested Omeprazole but if you’ve already been down that road it may be worth looking at the possibility of a new DMT. Good luck.