It’s unusual for you to be expressing your misery about your symptoms. I think you must be really suffering. I am sorry. MS is an absolute *¥€=;#!!
I only tried Sativex a couple of times some years ago. It tastes horrible and I didn’t feel it helped at all. I also tried some actual cannabis to see if that helped (a friend who smokes the stuff gave me some!). It didn’t, help that is. I believe that some people respond to CBD/THC (the active ingredients in Sativex and cannabis) and others don’t. I never have.
My rehab neurologist (lovely favourite doctor) did offer me a prescription for Sativex a while back but I refused on the grounds that I didn’t think it would work.
It does work for some people though, so if you’re given a prescription, it won’t hurt to give it a go. The drug leaves your system pretty easily and safely, so it won’t give you any bad side effects. It will just work or it won’t.
You’ve said you didn’t get on with any of the drugs you’ve tried for spasms an spasticity, but the ones you’ve listed are for neuropathic pain not spasticity. What about Baclofen, or Cloneazepam, even Diazepam? Personally, I couldn’t bear life without Baclofen. I take the maximum amount orally you’re supposed to take and sometimes have an extra one or two. I started taking Clonazepam when I noticed a sort of tremor, it felt like palpitations, but wasn’t. The Clonazepam helps immensely.
I think it takes a lot of trial and error to sort out drug treatments. I agree with you about being a zombie. Certainly Amitriptyline too late in the evening has a ‘hangover’ type feeling the next morning. For years I avoided taking it for that reason. But my rehab doctor (again) told me to take it by 7pm. That did the trick, I got used to it and now take it by 8.30 with no problems.
I hope you get something that just helps with the pain a bit and maybe gives you a good nights sleep.