Hi… I’ve been on Rebif since 2014, and it doesn’t do much for the fatigue; it’s still a nightmare, and when it kicks in, it feels like running into a wall. I can’t comment on Amantadine, as I tried it when I was first diagnosed (2013) and didn’t get on with it too well; made me very jumpy and sleepless - I was averaging about 3 hours sleep a night - so dumped it in favour of Rebif… maybe someone else has a better experience than me!