Was diagnosed with REMS about 11 years ago and have suffered from pain from the nerve damage pretty much since day 1. I started on gabapentin which was great but gradually had to increase the dosage up to the max. I moved onto pregablin with amatriptilene which did nothing so added duloxetine to the mix but still did very little. Replaced the pregablin with the gabapentin to see if that mixed with the other two would help but after a week it felt like I was just taking these for the sake of it. My best description of it is between feeling like someone is giving me injections all over my body but lately it’s more like when you’re frying bacon and the fat spits up and hits your arm but it is all over. The pain is getting too much, can’t concentrate at work and is starting to affect my mood. I’m also aware of my muscles reacting to these areas of a pain which is just tiring me out more. They tell me I have run out of options and the only way to go is morphine or methadone. I have an appointment on Wednesday to discuss this and wondered if I could hear from people who are taking either of these for nerve damage pain. Your experiences with these opiates would be very much appreciated.