When I first started taking duloxetine I was waking up at 2am unable to get back to sleep but this improved after about a week. I had been taking amitriptilyne before which had made me sleep for England!
But the real problem I had started a few weeks after starting it. I had a really bad taste in my mouth and mouth sores, as it was a while after starting the drug I didn’t think it was that. I went to the dentist because I was convinced it was coming from a wisdom tooth that look rotten to me.
But the dentist said the tooth was fine. But I had an extremely dry mouth which was causing the bad taste and I was grinding my teeth at night because they where sharp and I was biting the sides of my mouth hence the ulcers.
I had also put on a load of weight as I kept eating to cover the taste.
We tried a different manufacturer of the drug but this didn’t help so I came of it slowly.
I will say however, before I took it I was experiencing a burning sensation in my arms and legs, which duloxitine got under control. As soon as I stopped taking it the burning has come back with avengence.
I hope you have better luck than I did with the drug.