I haven’t taken Aubagio, but have Tecfidera.
Have you looked at https://www.mstrust.org.uk/understanding-ms/ms-symptoms-and-treatments/ms-decisions/decision-aid
You can compare the two drugs on there. If you notice the side effects list for Aubagio in detail, you’ll see that the list is actually as long as the list for Tecfidera.
And the benefits are much less for Aubagio than they are for Tecfidera.
Many people have minimised their side effects from the early effects of Tecfidera by slowing down the introduction of the drug. Normally, you start off with one week at a half dose twice per day, then move straight into the full dose twice a day in week two.
It might be possible to arrange for a much slower uptake. If you had one half dose each day on week one, two half doses in week two, one half and one full dose in week three, and only go for the full dose twice per day in week four, you might manage to reduce the early side effects.
You should also sandwich the dose between food stuffs as well. This does work.
Obviously side effects that stop you from taking the drug are possible on any of the DMDs. While I was still relapsing remitting, I had to stop taking 3 DMDs. The only one I didn’t have impossible side effects from was Copaxone. And in fact, if you were going for a DMD that gave as low a relapse reduction rate as Aubagio, I’d recommend you try to get Copaxone while it’s still available. Simply because the side effects profile is so much better than all of the other DMDs.
But if your choice is simply Aubagio and Tecfidera, I’d aim for the one that promises the least number of relapses. Don’t forget, 50% reduction is an average. Some people on Tecfidera just don’t have relapses. Or they are so mild as to be almost unnoticeable. And if you are going to take it, the wise Doctors on the Barts Blog have suggested that it works best when it’s the very first DMD a person has tried.
It is a difficult thing, just when you’re wrapping your head around the diagnosis, having to decide which of two offputting and serious drugs to put into your system is scary. Best of luck with your decision.