Anti-MOG disease vs MS?

I’ve just been tested positive for anti-mog disease, however I need to have another MRI scan on my brain to see if anything new has developed since my last one. And I had the diagnosis of Optic Neuritis. Has anyone got any knowledge of this? I can’t find out much about it. Also, could this develop into MS.

Hi Sam

I’ve just been having a look (Googling!) and I don’t think Anti-MOG can exactly turn into MS. I assume that more information will gradually appear with regard to anti-MOG, but the references I’ve found are all very academic (and hard/virtually impossible to read for a non scientist).

It looks to me that anti-MOG is a fairly recently defined demyelinating disease in its own right. Previously thought to be part of MS, it’s actually different.

Anti-MOG it seems is where a person has antibodies against Myelin Oligodendrocyte Glycoprotein. They tend to be absent in people with MS. The way the neurologists differentiate between the two is the shape of brain lesions.

There seems to be a strong connection to optic neuritis.

I’m sorry, I am a bit of a numpty when it comes to hard science, so that’s about all I can work out.

So I don’t know about treatments or prognosis or whether existing disease modifying drugs for MS would work nor whether steroids help, not even whether it’s a relapsing type of disease.

Someone a bit more savvy than me might be able to help (Dr Geoff maybe?)


In my time with MS; this is the first time I’ve heard of anti-MOG, and briefly going over it in Google; it’s the most relevant thing I’ve seen. The association with Optic Neuritis; Transverse Myelitis and Devic’s is uncanny.

What with this and the Charcot Project it seems at long last we are heading in the right direction.

Thank you Samward.