CityAssays Birmingham NHS path lab offer postal 25(OH)D testing for £25 UK.
I’m sure I don’t have to explain that MS is an inflammatory condition. If you want your body to be best able to resolve inflammation then 25(OH)D level needs to be at least 125nmol/l (as that is not only the natural level human DNA evolved to function best with but also the level at which it exerts it’s most potent anti inflammatory action.
For most people it will take 1000iu/daily Vitamin D3 for EACH 25lbs you weigh to get 25(OH)D in that range. Human skin would make 10,000iu ~20,000iu given the chance of FULL BODY NON BURNING MIDDAY SUMMER SUN exposure. But who gets the chance for that? In practice you need to use an EFFECTIVE amount of supplement for 3~6 months and then get a 25(OH)D blood spot test.to see how your body responds. Bigvits or Amazon have people selling 5000iu for around £12.50~£15 for a years supply. There is very little point in messing with prescription vitamin D3 the amounts are generally too low to be effective and often the form (ergocalciferol) that is least effective and has more side effects.
I think people have to apply a little common sense with Vitamin D3 it is ONE of several strategies our body uses to fight inflammation. Sure our DNA is set to produce vitamin D on our skin from dawn to dusk given UVB (sun) exposure but from dusk to dawn it’s also set to produce another anti inflammatory agent MELATONIN. We also have to remember that when humans evolved not only did they live naked outdoor lives and didn’t have light at night to stop melatonin secretion they also ONLY ate free range organic meat and veggies much higher in omega 3 than modern foods (omega 3 is another anti inflammatory agent. All the foods humans evolved with had higher magnesium status than current vegetables/grains. Modern farming has concentrated on higher yields and faster maturation so plants spend less time in soil and accumulate less magnesium now than even when we were kids. Magnesium is important because it’s required to operate the switch that enables calcidiol (the circulating form of vitamin d) to convert to CALCITRIOL (the active hormonal form)
So not only do you have to strive to raise 25(OH)D to 125nmol/l to maximize it’s anti-inflammatory action, you also have to ensure you MORE THAN MEET the rda for magnesium (most people don’t get current RDA so need to take slightly more to make up for the years of insufficiency) but also you need to improve MELATONIN secretion during the evening and through the night AND make sure you are getting plenty of omega 3 (fish oil) as well as reducing all your intakes of omega 6 oils (soy, corn, sunflower, safflower, cottonseed etc)
While it’s true that low vitamin d levels are associated with higher levels of disability and faster progression of the condition it’s also important to understand that if you want vitamin D to be effective not only have you to raise 25(OH)D to effective levlels but also understand the role of magnesium as a cofactor for vit d, and that the omega 3 DHA is a Vitamin D receptor ligand (it actively assists the action of vit d3) and that just about all the actions of vitamin D3 are matched by Melatonin so the BRIGHT LIGHT exposure that creates vitamin D at Midday is ALSO resetting your circadian rhythm so you are better able to make melatonin and sleep well and repair your body as you sleep through the night. If you wake up and put on the light at night then that’s your melatonin production stopped or seriously reduced.