As Smurf said, the titration regime is the key. 8 mcg, 22mcg and then full to 44 after a month. I have had the side effects twice since starting May. “Flu like symptoms” is a good description. Remember it is “flu like” - it is not flu itself. I felt stiff, achy, high temperature and a headache. However, unlike flu, the symptoms do tend to go away after about an hour or so after taking paracetamol. My regime is to take 2 x paracetamol at 9-00pm. Inject at 10-15pm and be in bed at 11-00pm. If I feel a bit muzzy in the morning, then another couple of paracetamols with breakfast. In the main, it is manageable, the Rebismart makes the injection process easy. The important thing for me is the use of a cold pack. Apply it for about 3 - 4 minutes prior to injecting, and you don’t feel much of the injection. For me omitting the cold pack makes the injection sting a bit. I hope it all goes well for you. Let us know how you’re getting on. Ian.