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Rebif withdrawal

My neuro recently suggested I have a 2 week break from Rebif which I have taken for 5 years. My diagnosis changed last year to Secondary MS from RRMS. Since then I’m absolutely exhausted, falling asleep & crying at slightest thing! I have recently been on pretty strenuous train tour of Germany/Austria so not sure if fatigue is because of this or a direct result of withdrawal from Rebif. Anyone out there experienced the same, or any thoughts on whether to give up Rebif or hang on? My neuro is leaving the decision to me. Judy