Hi guys - I’ve been on the Rebif now for a few weeks. Started on 22mg and pretty much sleep through any symtoms which is great. I inject Mon/Wed/Fri with the weekend off. My question is by Monday I feel dreadful. Its like a withdrawel of the drug or something. I can hardley concentrate Monday morning, my mood is extremely low but as soon as I’ve injected Monday night, I’m fine again for the rest of the week. Has anyone else experienced this? I’m thinking of asking my asking my nurse if I can inject Sunday night and then do a Tues/Thurs/Sat week alternatively. I wouldn’t be bothered but its affecting my work performance on a Monday which is a day I need to be on top form. I’m due to go on to 44mg soon and it may get worse!