Hello, I was on Plegridy for years. I found it i injected into fat (my belly after 3 kids ) my side effects weren’t as severe, just felt like rubbish for about 30 hours after but manageable with paracetamol.
If I injected into my thighs where I have a lot of muscle build up, my side effects were horrific and lasted up to 5 days!
My neurologist said it was fine for my to only inject in my belly, just alternate each side with each injection.
I think if you inject where you are least affected, and just rotate sides you should be fine! Avoid muscle!