I’ve been on Campath for three years now, previous to the first infusion I was literally having constant relapses despite being on Tysabri for over a year (and weekly injections of Interferons for 3 yrs before that). For the first five day infusion I was in a wheelchair when I went in the hospital and I was walking on crutches when I left a month later - though that might be the 2 wks of steroid infusion I had at the same time :). When I got my first infusion, Campath had not been approved for MS treatment yet and had actually been taken off the market to be re-branded so I was very lucky that my neuro was able to get his hands on some (I had to travel from Glasgow to Birmingham for the second treatment as it wasn’t approved for use in Scotland until the following year). The treatment now involves a 6 month course of anti-viral medication during and after, allergy medication during and the infusion of campath is immediately preceded by a steroid infusion making the total time you’re tied to the machine a whopping six hours a day! The first time I was given Campath they were still working out the procedure so the steroids were administered for five days prior as well as during so thank god they trimmed that down, lol.
After the first infusion I was relapse free for two years, a massive improvement as I had been relapsing at least every 3 months since 2007 - being able to walk for the last 2 Christmas’s has been a joy as before that was the period for my worst relapses. I had a third course this year as I had a minor relapse involving my sight and my nuero thought it best to have another round just in case.
I can’t praise Campath highly enough, it has been a life saver for me and I have not had any side effects so far - the worst side effects I’ve had have been from the IV steroids you get along with the Campath I have noticed some improvements in the damage relapses have left, and my nuero tells me that my last brain scan showed no new lesions as well as some improvement on old ones, so it was definitely a good decision for me to risk the side effects. Monthly blood tests for four years after a treatment seems like a small price to pay for me.
I still have fatigue symptoms but my doc put me on Amantidine which works great for me - I’m now an early riser and able to handle light housework for the first time in years Apparently Amantidine is for Parkinsons but has been shown to be effective for fatigue symptoms in MS, but it doesn’t work for everyone so doesn’t get prescribed much.
Hope all this blather helps, sorry for rattling on