Is anyone on fingolimod? I was on tysabri for 3yrs which worked well but I felt I should come off it because of the rising risk of PML. I have 3 young children. I had my first dose last week and I think I under-estimated the side effects. My heart rate went down to 38 and even 5 days after it would rise even if I exerted myself. I feel exhausted and my old pre-tysabri symptoms of numb, weak forearms and calves have returned already!!! Back pain too! I am presuming these will all settle. Does anyone have experience of Fingolimod and if so what difference (if any) had it made to your life. Any ongoing side effects??