I dont have an MS dx but it could be on the cards. Anyway I have an issue with the spinal cord causing walking problems and my neuro let me try fampridine. Unfortunately it didnt work.
I have had a long chat with my physio and after seeing many folk try fampridine she has come up with the following:
People with MS have walking problems due to :
a) Leg weakness (muscles not getting enough nerve impulse - lesion stops/prevents impulses getting down the cord)
b) spasticity/increased tone (One of the functions of the spinal cord is to dampen down impulses sent from the brain. If a lesion has caused this function to fail then the muscle will get too much impulse and be fired up too much)
c) combination of both (Some muscles get too much others too little).
Fampridine works by increasing the signal sent from the brain down the spinal cord. You dont need to be a scientist to work out what will happen. The weak muscles will get more impulse and get stronger BUT the spastic ones will also get even more and be fired up even more.
25% -30% of people with MS have walking problems due to weakness only (no spasticity) and will benefit from the drug.
If you just have spasticity then the drug will make your walking worse.
If you have both then one will counteract the other and you will probably notice no difference.
I thought it all made sence.