I would agree with what others have said RE getting lost. I get confused easily on routes I’m familiar with. Especially round abouts. I use a satnav most of the time to help with this. My reactions are otherwise unaffected. I do a lot of long distance diving (2-7 hrs) I tend to get quite stiff towards a long drive and drowsy towards the end which never uses to happen. I never used to take a break. Now I do, even if it’s just a 10 mins pit stop.