Chariot Trial

Symptoms and treatments
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Continuing the discussion from Tysabri and PML danger:

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I started the Chariot Trial taking Cladribine in September 2024. Within a matter of 2 weeks my Mobility worsened considerable. I was really feeling much more Mobile until taking this drug, I took two boxes before stopping as things became worse and worse. I have to admit my upper body felt better and less stiff, but not at the cost of my Mobility. The drug I was told stays in your system for 12 months, I would never have taken it if I had known this.

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That’s very bad luck and I am sorry. We sign up to these things in the hope of advancing science a little bit, but it’s very bad when we end up worse off.

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Thank you for your message Alison. I cannot believe that I heard yesterday that has now been licensed, and it will be fully available. The trial is still ongoing, it’s unbelievable now there will be a lot of unwitting people about to start taking it

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Are you sure it was Cladribine? Cladribine was approved in 2017 I think.

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The classic use of Cladribine is very specific with a number of tablets depending on your weight over a five day period then the same procedure repeated four weeks later. If there are no problems with lymphocytes or an infection it is repeated a year later.

The original post does not appear to following this protocol, so is it Cladribine?

For the record I had no problems with it though it does take some getting your head round the administration to start.

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As it was a trial it is possible that the administration of the drugs was altered so you would not know whether you were on Cladribine or a placebo or whatever drug they were using as a comparator.

No detailed knowledge of the trial, but if it is blinded you shouldn’t know if you are on Cladribine or not.

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Details of trial

All participants were randomly assigned to take either cladribine or a placebo (dummy drug) that they’ll take over the course of 24 months.

To work out whether the drug is effective, the researchers will assess arm and hand function using the nine-hole peg test. They’ll also be collecting MRI scans of participants to see whether cladribine shows an effect on lesions in the brain.

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