There is currently an article on the blog about when does progressive MS start and the following is a direct quote from Prof G, the main guy. I would really love to see him as a patient as he is so proactive. Has anyone seen him ?
“By the time PPMSers present they have probably had the disease for quite a long time. We need to try and diagnose PPMS ASAP and realise that we are dealing with two processes; (1) inflammation and (2) neurodegeneration. We therefore need to go back to the drawing board with our trial design and starting planning combination therapy strategies to tackle PPMS. I am not in the camp that thinks PPMS is an intractable problem. And yes I think PPMS will respond to highly-effective DMTs if they are started early enough and the trials are done long enough to account for therapeutic lag. However, anti-inflammatories will not be enough we will need to add neuroprotective drugs on top of them. An obvious combination supported by data is rituximab and laquinimod”