I list below the evidence that LDN can be considered as a DMD and as has already been said that does not include trials to licensing standards. However I think it is very important to realise that the older licensed DMD’s have little or no evidence to support any disease modifying effect / long term benefit. They are really only proven to reduce relapses. The newer ones have a proven disease modifying effect but this comes at the price of greater risk.
In the UK DMD’s are effectively rationed anyway so not everybody has that choice unless the can fund them privately.
http://www.mssociety.org.uk/what-is-ms/treatments-and-therapies/beta-interferon-and-glatiramer-acetate
The I would suggest the main evidence base is LDN is Anecdotal/ Clinical experience
http://www.ncbi.nlm.nih.gov/pubmed/15694688
25 years clinical experience
The medical conferences just a couple of links :-
http://glasgowldn2009.com/
A few very small clinical trials:-
http://www.lowdosenaltrexone.org/ldn_trials.htm
Confirmation that any doctor can prescribe LDN
http://www.publications.parliament.uk/pa/cm200405/cmhansrd/vo050302/text/50302w19.htm
House of commons written answer:-
http://www.publications.parliament.uk/pa/cm200405/cmhansrd/vo050302/text/50302w19.htm
Re confirmed in the recent debate on 8.12.11
http://www.publications.parliament.uk/pa/cm200405/cmhansrd/vo050302/text/50302w19.htm
Loads of scientific papers dating back years:-
http://www.ldnscience.org/
This is of course only the smallest snippet of the available evidence base.
When looking at the issues of evidence base for any treatment you also have to take into account that may trials are financed by vested interests so it is important to take this into account as well.
http://www.jsonline.com/features/health/drug-research-routinely-suppressed-study-authors-find-qd3kfnn-136625848.html
.
In the end it therefore must come to a personal choice of what you consider adequate evidence
I list below the evidence that LDN can be considered as a DMD and as has already been said that does not include trials to licensing standards. However I think it is very important to realise that the older licensed DMD’s have little or no evidence to support any disease modifying effect / long term benefit. They are really only proven to reduce relapses. The newer ones have a proven disease modifying effect but this comes at the price of greater risk.
In the UK DMD’s are effectively rationed anyway so not everybody has that choice unless the can fund them privately.
http://www.mssociety.org.uk/what-is-ms/treatments-and-therapies/beta-interferon-and-glatiramer-acetate
The I would suggest the main evidence base is LDN is Anecdotal/ Clinical experience
http://www.ncbi.nlm.nih.gov/pubmed/15694688
25 years clinical experience
The medical conferences just a couple of links :-
http://www.lowdosenaltrexone.org/events.htm
http://glasgowldn2009.com/
A few very small clinical trials:-
http://www.lowdosenaltrexone.org/ldn_trials.htm
Confirmation that any doctor can prescribe LDN
http://www.publications.parliament.uk/pa/cm200405/cmhansrd/vo050302/text/50302w19.htm
House of commons written answer:-
http://www.publications.parliament.uk/pa/cm200405/cmhansrd/vo050302/text/50302w19.htm
Re confirmed in the recent debate on 8.12.11
http://www.publications.parliament.uk/pa/cm200405/cmhansrd/vo050302/text/50302w19.htm
Loads of scientific papers dating back years:-
http://www.ldnscience.org/
This is of course only the smallest snippet of the available evidence base.
When looking at the issues of evidence base for any treatment you also have to take into account that may trials are financed by vested interests so it is important to take this into account as well.
http://www.jsonline.com/features/health/drug-research-routinely-suppressed-study-authors-find-qd3kfnn-136625848.html.
In the end it therefore must come to a personal choice of what you consider adequate evidence