My surgery usually prescribes 5 X 100mg of oral methylprednisolone per day for 5 days. IV steroids are usually 1000mg per day for 3 days. Not that it won’t be a good thing to have the higher dose if that’s what the neuro has specified, but your husband is going to find it quite hard going. Methyprednisolone causes some side effects that aren’t exactly unliveable with, but are not too pleasant either. I usually find that right from day one, I have an awful metallic taste in my mouth. It makes everything taste foul. Taking the pills with milk is much better than water. In fact milky drinks are the best option for mouth coating quality to help with the metal. (Normally I drink strong black coffee, so the fact that I was drinking frothy hot chocolate plus very milky coffee is an example of the problem.) Eating mints through the day quite often helps too. Secondly, steroids seriously muck up your sleep pattern. It’s really hard to get to sleep after say day 2. I take sleeping pills when I’m on steroids and it’s still hard. Doubling the dose is going to make it harder.
So, get prepared for a very tired, very grumpy man. An (extremely unlikely) listed potential side effect is psychosis. This gives you an idea of the teeth grinding cross being you’ll be living with for a week. I know he’s a man, but many women on steroids have found themselves washing the kitchen floor, rearranging the furniture, cleaning the bathroom etc in the middle of the night. So without generalising too much, make sure you have something for him to watch on telly, or a book to read, or a list of potential cleaning jobs if he’s that way inclined!
Re Vitamin D, I take 5000iu (international units) per day, when my levels are checked, I’m in the normal range. So once your husband has been on the dose the doctor has prescribed for a couple of months, get them to re test, to be sure it’s enough. You could double check this with his neurologist. I think most MS specialist neuros now recommend quite high doses of Vit D. But it is possible to take too much, so be guided by the doctors and the blood tests.
Good luck with the grizzly beast. I hope he’ll get a really good effect from the steroids and will soon be able to start a DMD.