# Tysabri failure

**URL:** <https://forum.mssociety.org.uk/t/tysabri-failure/81459>\
**Category:** Symptoms and treatments\
**Created:** [10 July 2026 18:07 UTC](https://forum.mssociety.org.uk/t/tysabri-failure/81459 "2026-07-10T18:07:57Z")\
**Posts on this page:** 2\
**Page:** 1

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**Author:** ![jmr](https://avatars.discourse-cdn.com/v4/letter/j/d6d6ee/32.png) [@jmr](https://forum.mssociety.org.uk/u/jmr)\
**Post date:** [10 July 2026 18:07 UTC](https://forum.mssociety.org.uk/t/tysabri-failure/81459/1 "2026-07-10T18:07:57Z")

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Unfortunately I’ve just been told I’ve failed tysabri. Been on it since MS diagnosis 11 months ago. Haven’t missed a dose had it 4 weekly. JCV -ve. Has this happened to anyone? I’ve been told to stop it and change to

- Alemtuzumab (Lemtrada)
- Ocrevus
- Kesimpta  
Or do HSCT  
It’s all very overwhelming

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**Author:** ![alison100](https://dub1.discourse-cdn.com/mssociety/user_avatar/forum.mssociety.org.uk/alison100/32/1019_2.png) [@alison100](https://forum.mssociety.org.uk/u/alison100)\
**Post date:** [11 July 2026 13:11 UTC](https://forum.mssociety.org.uk/t/tysabri-failure/81459/2 "2026-07-11T13:11:44Z")

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I am very sorry to read this. Please may I just add that Tysabri has failed you, not the other way round. That is very bad luck but it’s absolutely not your fault - the drug failed and that’s that.  
I hope that the next approach does the trick for you. My own view is that going for the most effective option available to me is probably best. Which is probably pretty much what you (like me) were thinking when you chose Tysabri in the first place. I am so sorry that it hasn’t done a better job for you - that must be so disappointing, right on top of the still fairly recent news of having MS in the first place.