I’ve been on Tysabri for nearly 3yrs and I’ve tolerated it well. My last relapses were in 2015, so I’ve now managed to get to 4yrs without a relapse, when the most I’ve ever got to was 3 - so its definitely working. I am obviously aware that Tysabri lowers your immune system and since I started it in March 2016, I’ve had a couple of horrendous chest infections, viruses, tonsilitus and strep throat. But the one thing thats bothering me is this - does Tysabri make you more susceptible to taking oral thrush? As I writing this I am nursing yet another bout of what I suspect is oral thrush and it really makes me feel like crap. My throat is bloomin agony and I have a stinker of a headache - great way to start the year lol. Just wondered if any other ‘Tysabrians’ out there have experienced anything similar? Your thoughts/advice etc is much appreciated. Steff X