I don’t use hot or cold pack. The injections on my thighs do sting more than anywhere else and sometimes my skin there gets very itchy but I rub Zerobase cream on them (my son has large tubs of it for his psoriasis). The stinging doesn’t last long and it’s a lot better than relapsing every few months which was my biggest fear before starting on Rebif
PS - Very proud of my son. He is on methatrexate for psoriasis and the tablets were irritating his stomach to the point that he was being violently sick for many days after taking the tablets (only taking them once a week). Blood tests showed that his liver was fine so there was no other reason to discontinue the drug and it has helped his psoriasis enormously, which btw is also an auto immune disorder. So he has had to switch to injections and yesterday he self injected for the first time. He uses single use syringes, no auto injector available. He injected into his stomach and although he was very scared he managed it himself even though the nurse offered to do it for him this time. He is only 19 but like he says, it’s better to self inject than it is to be sick all the time.