Fingolimod then Tysabri - bad news

The Barts blog spot has this report: http://multiple-sclerosis-research.blogspot.com/

It seems that a couple of people who’ve taken Tysabri (Alentuzumab) after having taken Fingolimod are at what they’ve called ‘increased risk of treatment failure’. It seems that these 2 individuals have developed a severe CNS condition. It’s curable with plasmapheresis - removing antibodies from the blood, but it’s not a good outcome at all. It does seem that what’s being reported is problems after a few months on Tysabri. So if you’ve been on it for a good while, even if you took Fingolimod first, you should be in the clear. But no reason not to check with your neurologist if you’re worried.

Sue

I am regularly confused by these drugs having at least three names, but I think Alentuzumab is Campath/Lemtrada and Tysabri is Natalizumab.

There was another lengthy blog on this subject recently, which had a few more details.

http://multiple-sclerosis-research.blogspot.com/2017/01/fingolimod-blocking-alemtuzumab-action.html

Oh. Silly of me. They do have stupid names. I wish someone would pick a name and stick to it. Surely we can handle long names? Lemtrada used to be Campath, which is of course Alemtuzumab. Actually, now the blogspot article makes more sense. (With regard to autoimmunities that is!)

Thanks for that. Now where is that edit button so I can change the title of the thread? Oh, yes I forgot, there isn’t one!

Sue

Hmm,

More than 3 syllables and what passes for my brain starts creaking

M

PS nothing much to do with my MS, I am just a bit thick, although in all seiousness I have found that my ability to take in complex or complicated information is more restricted in recent years.

M

I always read fingolimod as flamingo land. For those unaware where flamingo land is…It’s in Yorkshire of course!

Pollsx

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