To quote the first paragraph and give the essence of the article:-
GENE FLAW EXPLAINS WHY DRUGS FAILED TO TREAT MS
Scientists have identified why a once-promising class of drugs do not help people with multiple sclerosis.
An Oxford University team say an genetic variant linked to MS means the drugs which work for patients with other autoimmune diseases will not work for them.
The team, writing in Nature, say the drugs can actually make symptoms worse.
Experts say the work shows how a person’s genetic make-up could affect how they responded to treatment.
The drugs, called anti-TNFs, work for patients with rheumatoid arthritis and inflammatory bowel disease, but they have not done so for patients with MS and researchers were unsure why.