# ASCEND trial

**URL:** <https://forum.mssociety.org.uk/t/ascend-trial/25716>\
**Category:** Everyday living\
**Created:** [23 September 2012 22:27 UTC](https://forum.mssociety.org.uk/t/ascend-trial/25716 "2012-09-23T22:27:39Z")\
**Posts on this page:** 3\
**Page:** 1

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**Author:** ![Inactive\_User](https://avatars.discourse-cdn.com/v4/letter/i/3e96dc/32.png) [@Inactive\_User](https://forum.mssociety.org.uk/u/Inactive_User)\
**Post date:** [23 September 2012 22:27 UTC](https://forum.mssociety.org.uk/t/ascend-trial/25716/1 "2012-09-23T22:27:39Z")

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Hello,

Anybody out there on the ASCEND trial for tysabri for people with SPMS?

I had my first infusion at the start of September. How are you finding things, has it made any difference, do you feel better, did you have a lumbar puncture? So far not made any difference.

Its my first trial, the drugs I take are only to make the symptoms easier to live with, no DMT

I was diagnosed in 1995 but nothing significant happened until 2003 and since then it has been a slow skid down the slippery slope.

Regards,

Patrick

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<div class="post-metadata">

**Author:** ![Inactive\_User](https://avatars.discourse-cdn.com/v4/letter/i/3e96dc/32.png) [@Inactive\_User](https://forum.mssociety.org.uk/u/Inactive_User)\
**Post date:** [24 September 2012 16:39 UTC](https://forum.mssociety.org.uk/t/ascend-trial/25716/2 "2012-09-24T16:39:28Z")

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Hiya Patrick,

Had my 5th Infusion about 3 weeks ago and not noticed any differance or improvemant yet. I know its a double blind trial but i think i am on the Tysabri as had a nasty itchy/blotchy reaction during my 2nd infusion which i understand is quite common.

I didn’t have a lumbar puncture as i was told they weren’t doing them at the QE in Birmingham.

The trial is a big commitment but hopefully it will be worth it

John

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<div class="post-metadata">

**Author:** ![Inactive\_User](https://avatars.discourse-cdn.com/v4/letter/i/3e96dc/32.png) [@Inactive\_User](https://forum.mssociety.org.uk/u/Inactive_User)\
**Post date:** [22 January 2014 20:23 UTC](https://forum.mssociety.org.uk/t/ascend-trial/25716/3 "2014-01-22T20:23:06Z")

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Hello,

Just passed week 72 for this trial. Balance has got worse but EDSS stable at 7 and 9-peg test still at about 30 seconds. Problem is nobody knows if its a placebo.

I’m JC +ve so got to talk about continuation after 96 weeks. There are quite a few SPMS trials coming up.

Ah well must wait and see

Patrick

> **[life with multiple sclerosis](https://www.aid4disabled.com/)**
>
> Welcome to Aid4disabled. Patrick writes about his life with multiple sclerosis, Its all about his life or the ups, downs and falls